Combined alcoholic and non-alcoholic steatohepatitis

Non-alcoholic steatohepatitis

[Non-alcoholic fatty liver disease and non-alcoholic steatohepatitis].

Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are the hepatic manifestations of the metabolic syndrome. Since the prevalence of obesity and consequently of the metabolic syndrome is steadily increasing, the different types of NAFLD are nowadays the most common cause of liver injury in North America. The development of NASH and fatty liver cirrhosis occurs af...

Non-alcoholic steatohepatitis in children.

Non-alcoholic steatohepatitis (NASH) is an important liver disease in children; it can cause cirrhosis in children. The disease mechanism involves hepatic insulin resistance with hyperinsulinemia and changes in certain adipocytokines and inflammatory mediators. The differential diagnosis of childhood NASH includes metabolic disorders, drug hepatotoxicity, and alcoholic hepatitis in adolescent p...

Non-Alcoholic Steatohepatitis: Pathogenesis and Clinical Management

1Division of Gastroenterology, Ospedale di Acireale, Azienda Sanitaria Provinciale di Catania, Catania, Italy 2Liver Unit, Department of Gastroenterology, Tel-Aviv Medical Center, Tel-Aviv, Israel 3School of Public Health, University of Haifa, Haifa, Israel 4Department of Biomedical Sciences and Biotechnologies, University of Catania, Catania, Italy 5Center for Human Nutrition and Atkins Center...

Non-Alcoholic Steatohepatitis: Clinical and Translational Research.

UNLABELLED The present review includes translational and clinical research that characterize non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). Clinical and experimental evidence led to the recognition of the key toxic role played by lipotoxicity in the pathogenesis of NAFLD. The current understanding of lipotoxicity suggests that organ injury is initiated by th...